Posts tagged Relative Risk Reduction
NNT: Your Defense Against Modern Pharmaceutical Snake Oil Sales Tactics

Many popular pharmaceuticals are presented as miraculous cures when, in fact, they have much lower effectiveness than the sellers claim. As a result, most of us believe most medicines to be far more potent than they are and assume they have fewer side effects than in reality. We may be more likely to accept a prescription than not, by default, based more on faith in the results than the true knowledge of their effectiveness.  The term "Snake Oil" refers to a medical solution that is promoted as a cure-all for various illnesses but is fake and worthless. A snake oil salesman sells these useless products for a quick profit and then escapes to avoid the consequences. Many of these were salespeople who traveled from place to place selling their goods. Regrettably, these individuals frequently focused on vulnerable groups such as the elderly and those who are unwell. Some things never change. You may have noticed the numerous medication ads and cover stories on the news that make them sound so wonderful. Are the medications as effective as they say? The answer is, sadly, usually no. How did they get away with this? Read on to find out.

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How True Is The New Study That Claims Vitamin D Supplements Reduce the Risk of Alzheimer's Disease By 40%?

The connection between Alzheimer's disease (AD) and vitamin D status has been known for some time. A 2015 review of the literature concluded that being deficient in vitamin D presented a 21% greater chance of developing Alzheimer's compared to those with adequate levels of vitamin D above 50 nmol/L. Researchers at the University of Calgary's Hotchkiss Brain Institute in Canada and the University of Exeter in England explored the relationship between vitamin D supplementation and dementia in more than 12,388 subjects. They found that subjects who had a history of vitamin D supplementation were 40% less likely to develop Alzheimer’s disease. The results are exaggerated due to normal statistical trickery, but there is still a strong correlation. I will break the study down and explain the real results. I will also give my two cents on whether you should supplement.

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The Vitamin D, Statin, and Cholesterol Paradox

The major precursor of vitamin D is cholesterol. Without cholesterol, we cannot make it. Some people may find this shocking because vitamin D is highly praised, while cholesterol is demonized. Since vitamin D and cholesterol are so closely related, they have an interesting interplay. Statin drugs, which lower cholesterol, also take part in the interplay. The enzyme statins block is active at step two, so we would expect less production of all molecules in the cholesterol pathway, like CoQ10. Statins should block vitamin D production, but they don’t. Statins are supposed to lower your risk of heart disease. But by how much? You may be surprised by the answer. This post will cover the synthesis of cholesterol, vitamin D, and Co Q10 and discuss how statins alter the pathways.

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